报告人简介：

  李明，中国科学院微生物研究所研究员，获国家自然科学基金优秀青年基金、国家原创探索计划项目资助，入选中科院青年创新促进会会员，中国科协青年人才托举工程。聚焦微生物CRISPR等噬菌体防御机制的理论研究，以及基因编辑、CRISPR杀菌剂等新型工具的开发，以通讯作者发表Science、Nature Communications、Nucleic Acids Res等论文，回答了CRISPR适应领域长期关注的若干基本科学问题，并在国际上首次发现了CRISPR的护卫RNA系统，推动并引领了该国际热点领域的研究。

近五年代表性工作：

1.Li M#*, Gong L#, Cheng F#, Yu H, Zhao D, Wang R, Wang T, Zhang S, Zhou J, Shmakov S, Koonin E, Xiang H*. (2021) Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems. Science. 372(6541):eabe5601.

2.Wang R#, Shu X#, Zhao H#, Xue Q, Liu C, Wu A, Cheng F, Wang L, Zhang Y, Feng J, Wu N, Li M*. (2023) Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens. Nat Commun.14(1):2078.

3.Cheng F#, Wu A#, Liu C#, Cao X, Wang R, Shu X, Wang L, Zhang Y, Xiang H*, Li M*. (2022) The toxin-antitoxin RNA guards of CRISPR-Cas evolved high specificity through repeat degeneration. Nucleic Acids Research. 50(16):9442-9452.

4.Cheng F#, Wang R#, Yu H#, Liu C, Yang J, Xiang H*, Li M*. (2021) Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins. Nucleic Acids Research. 49(18):10677-10688.

5.Xu Z#, Li M#, Li Y, Cao H, Miao L, Xu Z, Higuchi Y, Yamasaki S, Nishino K, Woo PCY, Xiang H*, Yan A*. (2019). Native CRISPR-Cas-Mediated Genome Editing Enables Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa. Cell Reports. 29(6):1707-1717.

6.Gong L, Li M*, Cheng F, Zhao D, Chen Y, Xiang H*. (2019) Primed adaptation tolerates extensive structural and size variations of the CRISPR RNA guide in Haloarcula hispanica. Nucleic Acids Research. 47(11):5880-91.